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apalutamide will lessen the extent or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with prescription drugs that happen to be CYP3A4 substrates may lead to reduce exposure to those medications.The event of dihydrocodeine for a pai